SDF-1α and β are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1α and β chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1α and β contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1α protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Human SDF-1α is an 8.0 kDa protein containing 68 amino acid residues.
Source:
E.coli
Status：Lyophilized powder
Synonyms:
Stromal-Cell Derived Factor-1, CXCL12, PBSF
AA Sequence（C terminal contains His tag）:
KPVSLSYRCPCRFFESHIARANVKHLKILNTPNCALQIVA RLKNNNRQVCIDPKLKWIQEYLEKALNKLEHHHHHH
Purity:
≥ 98% by SDS-PAGE gel
Biological Activity:
Determined by its ability to chemoattract human peripheral T cells activated with PHA and IL-2 using a concentation of 20-80 ng/ml.
Calculated Molecular Weight:
9.0 kDa
Accession Number:
P40224
Gene ID:
20315
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