Quantity: 100 µg
MW: 20 kDa
Source: E. coli­ derived
Stock: PBS pH 7.0, 1 mM DTT
Purity: >95%, by SDS­PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain. 
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- 13844081467
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UBE2C/UbcH10
| 產(chǎn)品編號(hào) | 規(guī)格 | 價(jià)格 | 貨期 | |
| UBE-654 | 100μg | ￥1280 | 現(xiàn)貨 |
- 產(chǎn)品描述
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Ubiquitinconjugating Enzyme H10 (UbcH10), also known as Ubiquitinconjugating Enzyme E2C (UBE2C), is a 179 amino acid (aa) member of the yeast Ubc4/5 family of Ubiquitin Conjugating Enzymes (E2) and has a predicted molecular weight of 20 kDa. Human UbcH10/UBE2C shares 96% aa sequence identity with mouse and rat UBE2C. UbcH10/UBE2C is an essential mediator of mitotic destruction events and cell cycle progression. UbcH10/UBE2C recognizes TEK sequences in target proteins such as Cyclins A and B, mediates Lys11linked ubiquitination, and promotes target protein degradation in conjunction with APC/C, a Ubiquitin Ligase (E3). The catalytic activity of UbcH10/UBE2C is regulated by a conserved N-terminal extension, which mediates E2E3 interaction. UbcH10/UBE2C is overexpressed in a variety of human cancers, and alternate splice isoforms may contribute to uncontrolled cell proliferation and tumor progression.