Formulation: 20mM Tris-HCl, pH 7.5, 0.15 M NaCl
Quality Control
Purity: >95% as determined by SDS-PAGE
Storage: Store at -80 ℃, avoid multiple freeze/thaw cycles
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K48-linked Tetra-Ubiquitin
| 產(chǎn)品編號 | 規(guī)格 | 價格 | 貨期 | |
| UBC-484 | 25ug | ￥2450 | 現(xiàn)貨 |
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K48-linked Tetra-Ubiquitin
Cat. # UBC-484
Product specification: 25 μg /vial
General lnformation
Poly-ubiquitylation of target proteins through linkage at K48, is now the most thoroughly studied of the various chain linkages, and was once considered the hallmark of this post- translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkage remains a critical pathway for the cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself. These di-ubiquitin chains are generated from the enzymatic linkage (E2-25K) of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for a lysine at position 48, limiting the chain length.
